A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets

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Despite -or maybe because- many shortcomings, Heckel's equation is by far the most investigated compressibility model for decades. The somewhat overlooked Gurnham equation is proposed as a more stable and better fitting compressibility model. Combining this equation with a linear model for the strength/pressure relation provides a composite function identical with the often-used Ryshkewitch equation for the relation between strength and porosity. It is thus questioned whether the three-dimensional compression characterization presented in USP monograph <1062> is correct. Substantial errors in computed parameters are revealed with consequences for reproducibility or inter-lab assessments. Elastic recovery is proposed as a more interesting and relevant characteristic in relation to pharmaceutical tablet formulation.

OriginalsprogEngelsk
TidsskriftJournal of Pharmaceutical Sciences
Vol/bind111
Udgave nummer11
Sider (fra-til)3088-3095
ISSN0022-3549
DOI
StatusUdgivet - 2022

Bibliografisk note

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© 2022 American Pharmacists Association

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