A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Despite -or maybe because- many shortcomings, Heckel's equation is by far the most investigated compressibility model for decades. The somewhat overlooked Gurnham equation is proposed as a more stable and better fitting compressibility model. Combining this equation with a linear model for the strength/pressure relation provides a composite function identical with the often-used Ryshkewitch equation for the relation between strength and porosity. It is thus questioned whether the three-dimensional compression characterization presented in USP monograph <1062> is correct. Substantial errors in computed parameters are revealed with consequences for reproducibility or inter-lab assessments. Elastic recovery is proposed as a more interesting and relevant characteristic in relation to pharmaceutical tablet formulation.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Pharmaceutical Sciences |
Vol/bind | 111 |
Udgave nummer | 11 |
Sider (fra-til) | 3088-3095 |
ISSN | 0022-3549 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Publisher Copyright:
© 2022 American Pharmacists Association
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