A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets

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Standard

A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets. / Sonnergaard, Jørn M.

I: Journal of Pharmaceutical Sciences, Bind 111, Nr. 11, 2022, s. 3088-3095.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sonnergaard, JM 2022, 'A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets', Journal of Pharmaceutical Sciences, bind 111, nr. 11, s. 3088-3095. https://doi.org/10.1016/j.xphs.2022.07.007

APA

Sonnergaard, J. M. (2022). A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets. Journal of Pharmaceutical Sciences, 111(11), 3088-3095. https://doi.org/10.1016/j.xphs.2022.07.007

Vancouver

Sonnergaard JM. A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets. Journal of Pharmaceutical Sciences. 2022;111(11):3088-3095. https://doi.org/10.1016/j.xphs.2022.07.007

Author

Sonnergaard, Jørn M. / A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets. I: Journal of Pharmaceutical Sciences. 2022 ; Bind 111, Nr. 11. s. 3088-3095.

Bibtex

@article{bfc82362ed774b398c53b72e161d9385,
title = "A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets",
abstract = "Despite -or maybe because- many shortcomings, Heckel's equation is by far the most investigated compressibility model for decades. The somewhat overlooked Gurnham equation is proposed as a more stable and better fitting compressibility model. Combining this equation with a linear model for the strength/pressure relation provides a composite function identical with the often-used Ryshkewitch equation for the relation between strength and porosity. It is thus questioned whether the three-dimensional compression characterization presented in USP monograph <1062> is correct. Substantial errors in computed parameters are revealed with consequences for reproducibility or inter-lab assessments. Elastic recovery is proposed as a more interesting and relevant characteristic in relation to pharmaceutical tablet formulation.",
keywords = "Compaction, Compression, Factorial design, Mathematical models, Tablets",
author = "Sonnergaard, {J{\o}rn M.}",
note = "Publisher Copyright: {\textcopyright} 2022 American Pharmacists Association",
year = "2022",
doi = "10.1016/j.xphs.2022.07.007",
language = "English",
volume = "111",
pages = "3088--3095",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - A Simplified Model Structure for Compression Characterization of Pharmaceutical Tablets

AU - Sonnergaard, Jørn M.

N1 - Publisher Copyright: © 2022 American Pharmacists Association

PY - 2022

Y1 - 2022

N2 - Despite -or maybe because- many shortcomings, Heckel's equation is by far the most investigated compressibility model for decades. The somewhat overlooked Gurnham equation is proposed as a more stable and better fitting compressibility model. Combining this equation with a linear model for the strength/pressure relation provides a composite function identical with the often-used Ryshkewitch equation for the relation between strength and porosity. It is thus questioned whether the three-dimensional compression characterization presented in USP monograph <1062> is correct. Substantial errors in computed parameters are revealed with consequences for reproducibility or inter-lab assessments. Elastic recovery is proposed as a more interesting and relevant characteristic in relation to pharmaceutical tablet formulation.

AB - Despite -or maybe because- many shortcomings, Heckel's equation is by far the most investigated compressibility model for decades. The somewhat overlooked Gurnham equation is proposed as a more stable and better fitting compressibility model. Combining this equation with a linear model for the strength/pressure relation provides a composite function identical with the often-used Ryshkewitch equation for the relation between strength and porosity. It is thus questioned whether the three-dimensional compression characterization presented in USP monograph <1062> is correct. Substantial errors in computed parameters are revealed with consequences for reproducibility or inter-lab assessments. Elastic recovery is proposed as a more interesting and relevant characteristic in relation to pharmaceutical tablet formulation.

KW - Compaction

KW - Compression

KW - Factorial design

KW - Mathematical models

KW - Tablets

U2 - 10.1016/j.xphs.2022.07.007

DO - 10.1016/j.xphs.2022.07.007

M3 - Journal article

C2 - 35839865

AN - SCOPUS:85135510446

VL - 111

SP - 3088

EP - 3095

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 11

ER -

ID: 318194893