Rapid Prototyping of Miniaturized Powder Mixing Geometries

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Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.

OriginalsprogEngelsk
TidsskriftJournal of Pharmaceutical Sciences
Vol/bind110
Udgave nummer7
Sider (fra-til)2625-2628
ISSN0022-3549
DOI
StatusUdgivet - 2021

Bibliografisk note

Funding Information:
Authors would like to acknowledge the Independent Research Fund Denmark [Grant No. 8022-00154B] for financial support for this project.

Publisher Copyright:
© 2021 The Authors

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