Permeation of chromium salts through human skin in vitro

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Standard

Permeation of chromium salts through human skin in vitro. / Gammelgaard, Bente; Fullerton, A; Avnstorp, C; Menné, T.

I: Contact Dermatitis, Bind 27, Nr. 5, 1992, s. 302-10.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gammelgaard, B, Fullerton, A, Avnstorp, C & Menné, T 1992, 'Permeation of chromium salts through human skin in vitro', Contact Dermatitis, bind 27, nr. 5, s. 302-10.

APA

Gammelgaard, B., Fullerton, A., Avnstorp, C., & Menné, T. (1992). Permeation of chromium salts through human skin in vitro. Contact Dermatitis, 27(5), 302-10.

Vancouver

Gammelgaard B, Fullerton A, Avnstorp C, Menné T. Permeation of chromium salts through human skin in vitro. Contact Dermatitis. 1992;27(5):302-10.

Author

Gammelgaard, Bente ; Fullerton, A ; Avnstorp, C ; Menné, T. / Permeation of chromium salts through human skin in vitro. I: Contact Dermatitis. 1992 ; Bind 27, Nr. 5. s. 302-10.

Bibtex

@article{4f6da19d265b458d9bc15032cdf413b5,
title = "Permeation of chromium salts through human skin in vitro",
abstract = "Chromium permeation studies were performed on full thickness human skin in diffusion cells. All samples were analysed for the total chromium content by graphite furnace Zeeman-corrected atomic absorption spectrometry. Some samples were analysed by an ion chromatographic method permitting the simultaneous determination of Cr(VI) and Cr(III) as well. The amounts of chromium found in all skin layers were significantly higher when potassium dichromate was applied to the skin compared with chromium chloride or chromium nitrate. Chromium could only be detected in the recipient phase after application of the dichromate solution. Chromium skin levels increased with increasing concentrations of applied chromium salts up to 0.034 M Cr. The amount of chromium in recipient phase and skin layers increased with increasing pH when the applied solution contained potassium dichromate. This was ascribed to a decreased skin barrier function of the skin. The amount of chromium found in all skin layers after application of chromium chloride decreased with increasing pH due to lower solubility of the salt. The % of chromium found in the recipient phase as chromium(VI) increased with increasing total chromium concentration indicating a limited reduction ability of the skin in vitro.",
keywords = "Chlorides, Chromium, Chromium Compounds, Female, Humans, Hydrogen-Ion Concentration, Permeability, Potassium Dichromate, Skin, Solutions",
author = "Bente Gammelgaard and A Fullerton and C Avnstorp and T Menn{\'e}",
year = "1992",
language = "English",
volume = "27",
pages = "302--10",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Permeation of chromium salts through human skin in vitro

AU - Gammelgaard, Bente

AU - Fullerton, A

AU - Avnstorp, C

AU - Menné, T

PY - 1992

Y1 - 1992

N2 - Chromium permeation studies were performed on full thickness human skin in diffusion cells. All samples were analysed for the total chromium content by graphite furnace Zeeman-corrected atomic absorption spectrometry. Some samples were analysed by an ion chromatographic method permitting the simultaneous determination of Cr(VI) and Cr(III) as well. The amounts of chromium found in all skin layers were significantly higher when potassium dichromate was applied to the skin compared with chromium chloride or chromium nitrate. Chromium could only be detected in the recipient phase after application of the dichromate solution. Chromium skin levels increased with increasing concentrations of applied chromium salts up to 0.034 M Cr. The amount of chromium in recipient phase and skin layers increased with increasing pH when the applied solution contained potassium dichromate. This was ascribed to a decreased skin barrier function of the skin. The amount of chromium found in all skin layers after application of chromium chloride decreased with increasing pH due to lower solubility of the salt. The % of chromium found in the recipient phase as chromium(VI) increased with increasing total chromium concentration indicating a limited reduction ability of the skin in vitro.

AB - Chromium permeation studies were performed on full thickness human skin in diffusion cells. All samples were analysed for the total chromium content by graphite furnace Zeeman-corrected atomic absorption spectrometry. Some samples were analysed by an ion chromatographic method permitting the simultaneous determination of Cr(VI) and Cr(III) as well. The amounts of chromium found in all skin layers were significantly higher when potassium dichromate was applied to the skin compared with chromium chloride or chromium nitrate. Chromium could only be detected in the recipient phase after application of the dichromate solution. Chromium skin levels increased with increasing concentrations of applied chromium salts up to 0.034 M Cr. The amount of chromium in recipient phase and skin layers increased with increasing pH when the applied solution contained potassium dichromate. This was ascribed to a decreased skin barrier function of the skin. The amount of chromium found in all skin layers after application of chromium chloride decreased with increasing pH due to lower solubility of the salt. The % of chromium found in the recipient phase as chromium(VI) increased with increasing total chromium concentration indicating a limited reduction ability of the skin in vitro.

KW - Chlorides

KW - Chromium

KW - Chromium Compounds

KW - Female

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Permeability

KW - Potassium Dichromate

KW - Skin

KW - Solutions

M3 - Journal article

C2 - 1493684

VL - 27

SP - 302

EP - 310

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 5

ER -

ID: 44053602