Ockham's Razor Applied on Pharmaceutical Powder Compaction Models
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Ockham's Razor Applied on Pharmaceutical Powder Compaction Models. / Sonnergaard, Jørn M.
I: Journal of Pharmaceutical Sciences, Bind 110, Nr. 3, 2021, s. 989-996.Publikation: Bidrag til tidsskrift › Leder › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ockham's Razor Applied on Pharmaceutical Powder Compaction Models
AU - Sonnergaard, Jørn M.
PY - 2021
Y1 - 2021
N2 - This investigation contains a critical survey of a collection of five well-known and often used standard models in pharmaceutical technology. The basic idea is to use the recognised Ockham's razor as a tool in search for simpler methods or explanations for these models. The study includes the indirect tensile strength of tablets, Pitt's equation for tensile strength of biconvex tablets, Adams' model for strength of agglomerates, Weibull's distribution for variability of strength measurements and Heckel's equation for compressibility. In all these cases simpler and equally valid solutions and explanations are presented and subsequently preferred rather than the original.
AB - This investigation contains a critical survey of a collection of five well-known and often used standard models in pharmaceutical technology. The basic idea is to use the recognised Ockham's razor as a tool in search for simpler methods or explanations for these models. The study includes the indirect tensile strength of tablets, Pitt's equation for tensile strength of biconvex tablets, Adams' model for strength of agglomerates, Weibull's distribution for variability of strength measurements and Heckel's equation for compressibility. In all these cases simpler and equally valid solutions and explanations are presented and subsequently preferred rather than the original.
KW - Compaction
KW - Factorial design
KW - Mathematical models
KW - Mechanical properties
KW - Physical characterization
KW - Crushing strength
U2 - 10.1016/j.xphs.2020.11.026
DO - 10.1016/j.xphs.2020.11.026
M3 - Editorial
C2 - 33271138
VL - 110
SP - 989
EP - 996
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 3
ER -
ID: 261219628