Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.
Originalsprog | Engelsk |
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Tidsskrift | Angewandte Chemie (International ed. in English) |
Vol/bind | 56 |
Udgave nummer | 14 |
Sider (fra-til) | 3901-3905 |
Antal sider | 5 |
ISSN | 1433-7851 |
DOI | |
Status | Udgivet - 27 mar. 2017 |
ID: 185437793