Modulatory Effect of Human Plasma on the Internal Nanostructure and Size Characteristics of Liquid-Crystalline Nanocarriers
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Modulatory Effect of Human Plasma on the Internal Nanostructure and Size Characteristics of Liquid-Crystalline Nanocarriers. / Mat Azmi, Intan Diana Binti; Wu, Linping; Wibroe, Peter Popp; Nilsson, Christa; Østergaard, Jesper; Stürup, Stefan; Gammelgaard, Bente; Urtti, Arto; Moghimi, Seyed Moein; Yaghmur, Anan.
I: Langmuir, Bind 31, Nr. 18, 30.04.2015, s. 5042–49.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Modulatory Effect of Human Plasma on the Internal Nanostructure and Size Characteristics of Liquid-Crystalline Nanocarriers
AU - Mat Azmi, Intan Diana Binti
AU - Wu, Linping
AU - Wibroe, Peter Popp
AU - Nilsson, Christa
AU - Østergaard, Jesper
AU - Stürup, Stefan
AU - Gammelgaard, Bente
AU - Urtti, Arto
AU - Moghimi, Seyed Moein
AU - Yaghmur, Anan
PY - 2015/4/30
Y1 - 2015/4/30
N2 - The inverted-type liquid-crystalline dispersions comprising cubosomes and hexosomes hold much potential for drug solubilization and site-specific targeting on intravenous administration. Limited information, however, is available on the influence of plasma components on nanostructural and morphological features of cubosome and hexosome dispersions, which may modulate their stability in the blood and their overall biological performance. Through an integrated approach involving SAXS, cryo-TEM, and nanoparticle tracking analysis (NTA) we have studied the time-dependent effect of human plasma (and the plasma complement system) on the integrity of the internal nanostructure, morphology, and fluctuation in size distribution of phytantriol (PHYT)-based nonlamellar crystalline dispersions. The results indicate that in the presence of plasma the internal nanostructure undergoes a transition from the biphasic phase (a bicontinuous cubic phase with symmetry Pn3m coexisting with an inverted-type hexagonal (H2) phase) to a neat hexagonal (H2) phase, which decreases the median particle size. These observations were independent of a direct effect by serum albumin and dispersion-mediated complement activation. The implication of these observations in relation to soft nanocarrier design for intravenous drug delivery is discussed.
AB - The inverted-type liquid-crystalline dispersions comprising cubosomes and hexosomes hold much potential for drug solubilization and site-specific targeting on intravenous administration. Limited information, however, is available on the influence of plasma components on nanostructural and morphological features of cubosome and hexosome dispersions, which may modulate their stability in the blood and their overall biological performance. Through an integrated approach involving SAXS, cryo-TEM, and nanoparticle tracking analysis (NTA) we have studied the time-dependent effect of human plasma (and the plasma complement system) on the integrity of the internal nanostructure, morphology, and fluctuation in size distribution of phytantriol (PHYT)-based nonlamellar crystalline dispersions. The results indicate that in the presence of plasma the internal nanostructure undergoes a transition from the biphasic phase (a bicontinuous cubic phase with symmetry Pn3m coexisting with an inverted-type hexagonal (H2) phase) to a neat hexagonal (H2) phase, which decreases the median particle size. These observations were independent of a direct effect by serum albumin and dispersion-mediated complement activation. The implication of these observations in relation to soft nanocarrier design for intravenous drug delivery is discussed.
U2 - 10.1021/acs.langmuir.5b00830
DO - 10.1021/acs.langmuir.5b00830
M3 - Journal article
C2 - 25884233
VL - 31
SP - 5042
EP - 5049
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 18
ER -
ID: 137372735