Determining Thermal Conductivity of Small Molecule Amorphous Drugs with Modulated Differential Scanning Calorimetry and Vacuum Molding Sample Preparation
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Dokumenter
- pharmaceutics-11-00670-v2
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Thermal conductivity is a material specific property, which influences many aspects of pharmaceutical development, such as processing, modelling, analysis, and the development of novel formulation approaches. We have presented a method to measure thermal conductivity of small molecule organic glasses, based on a vacuum molding sample preparation technique combined with modulated differential scanning calorimetry. The method is applied to the two amorphous model compounds indomethacin and celecoxib. The measured values of below 0.2 W/m °C indicate very low thermal conductivity of the amorphous compounds, within the range of organic liquids and low conducting polymers.
Originalsprog | Engelsk |
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Artikelnummer | 670 |
Tidsskrift | Pharmaceutics |
Vol/bind | 11 |
Udgave nummer | 12 |
Antal sider | 7 |
ISSN | 1999-4923 |
DOI | |
Status | Udgivet - 6 dec. 2019 |
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