Delivery systems for antimicrobial peptides
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Due to rapidly increasing resistance development against conventional antibiotics, finding novel approaches for the treatment of infections has emerged as a key health issue. Antimicrobial peptides (AMPs) have attracted interest in this context, and there is by now a considerable literature on the identification such peptides, as well as on their optimization to reach potent antimicrobial and anti-inflammatory effects at simultaneously low toxicity against human cells. In comparison, delivery systems for antimicrobial peptides have attracted considerably less interest. However, such delivery systems are likely to play a key role in the development of potent and safe AMP-based therapeutics, e.g., through reducing chemical or biological degradation of AMPs either in the formulation or after administration, by reducing adverse side-effects, by controlling AMP release rate, by promoting biofilm penetration, or through achieving co-localization with intracellular pathogens. Here, an overview is provided of the current understanding of delivery systems for antimicrobial peptides, with special focus on AMP-carrier interactions, as well as consequences of these interactions for antimicrobial and related biological effects of AMP-containing formulations.
Originalsprog | Engelsk |
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Tidsskrift | Advances in Colloid and Interface Science |
Vol/bind | 242 |
Sider (fra-til) | 17-34 |
Antal sider | 18 |
ISSN | 0001-8686 |
DOI | |
Status | Udgivet - apr. 2017 |
ID: 185031634