Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting--a review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • J Axel Zeitler
  • Philip F Taday
  • David A Newnham
  • Michael Pepper
  • Keith C Gordon
  • Rades, Thomas
Terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) are two novel techniques for the physical characterization of pharmaceutical drug materials and final solid dosage forms, utilizing spectral information in the far infrared region of the electromagnetic spectrum. This review focuses on the development and performance of pharmaceutical applications of terahertz technology compared with other tools for physical characterization. TPS can be used to characterize crystalline properties of drugs and excipients. Different polymorphic forms of a drug can be readily distinguished and quantified. Recent developments towards a better understanding of the fundamental theory behind spectroscopy in the far infrared have been discussed. Applications for TPI include the measurement of coating thickness and uniformity in coated pharmaceutical tablets, structural imaging and 3D chemical imaging of solid dosage forms.
OriginalsprogEngelsk
TidsskriftJournal of Pharmacy and Pharmacology
Vol/bind59
Udgave nummer2
Sider (fra-til)209-23
Antal sider15
ISSN0022-3573
DOI
StatusUdgivet - 2007
Eksternt udgivetJa

ID: 40357086