Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.
Originalsprog | Engelsk |
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Tidsskrift | Molecular Pharmaceutics |
Vol/bind | 16 |
Udgave nummer | 8 |
Sider (fra-til) | 3678-3686 |
Antal sider | 9 |
ISSN | 1543-8384 |
DOI | |
Status | Udgivet - 2019 |
ID: 241110495