Intrinsic and Dynamic Heterogeneity of Nonlamellar Lyotropic Liquid Crystalline Nanodispersions
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Nonlamellar lyotropic liquid crystalline (LLC) nanoparticles are a family of versatile nano-self-assemblies, which are finding increasing applications in drug solubilization and targeted drug delivery. LLC nanodispersions are heterogeneous with discrete nanoparticle subpopulations of distinct internal architecture and morphology, frequently coexisting with micelles and/or vesicles. Diversity in the internal architectural repertoire of LLC nanodispersions grants versatility in drug solubilization, encapsulation, and release rate. However, drug incorporation contributes to the heterogeneity of LLC nanodispersions, and on exposure to biological media, LLC nanodispersions often undergo nanostructural and morphological transformations. From a pharmaceutical perspective, coexistence of multiple types of nanoparticles with diverse structural attributes, together with media-driven transformations in colloidal characteristics, brings challenges in dissecting biological and therapeutic performance of LLC nanodispersions in a spatiotemporal manner. Here, we outline innate and acquired heterogeneity of LLC nanodispersions and discuss technological developments and alternative approaches needed to improve homogeneity of LLC formulations for drug delivery applications.
Originalsprog | Engelsk |
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Tidsskrift | ACS Nano |
Vol/bind | 17 |
Udgave nummer | 22 |
Sider (fra-til) | 22183–22195 |
ISSN | 1936-0851 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
S.M.M. acknowledges support by the European Union’s Horizon 2020 programme funded under H2020-EU.1.3. – Excellent Science – Marie Sklodowska-Curie Actions, grant agreement ID. 956544 (DIRNANO: Directing the Immune Response through designed NANOmaterials). A.Y. and S.M.M. acknowledge support by the Danish Council for Independent Research – Technology and Production Sciences; references DFF-3105-00039B, DFF-7017-00065, and 1335-00150b. A.Y. further acknowledges financial support by Novo Nordisk Foundation (Grant number NNF22OC0079752) and the Danish Natural Sciences Research Council (DanScatt) for SAXS experiments.
Publisher Copyright:
© 2023 American Chemical Society
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