Acheta domesticus: A Natural Source of Anti-Skin-Aging Ingredients for Cosmetic Applications
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Acheta domesticus : A Natural Source of Anti-Skin-Aging Ingredients for Cosmetic Applications. / Yeerong, Kankanit; Chantawannakul, Panuwan; Anuchapreeda, Songyot; Rades, Thomas; Müllertz, Anette; Chaiyana, Wantida.
I: Pharmaceuticals, Bind 17, Nr. 3, 346, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Acheta domesticus
T2 - A Natural Source of Anti-Skin-Aging Ingredients for Cosmetic Applications
AU - Yeerong, Kankanit
AU - Chantawannakul, Panuwan
AU - Anuchapreeda, Songyot
AU - Rades, Thomas
AU - Müllertz, Anette
AU - Chaiyana, Wantida
N1 - Publisher Copyright: © 2024 by the authors.
PY - 2024
Y1 - 2024
N2 - Acheta domesticus is an edible insect, rich in nutritional value and considered a sustainable protein source. This study aimed to investigate the potential application of A. domesticus extracts for anti-skin-aging purposes. The extracts were prepared by maceration at ambient temperature with 95% ethanol or hexane and maceration in gentle heat (45 °C) with 95% v/v ethanol or DI water. The extracts were examined for total protein, phenolic, and flavonoid contents. Protein molecular weight distribution was analyzed. The safety of the extracts was investigated in terms of irritation and cytotoxicity. Biological activities relevant to the inhibition of skin aging were evaluated, including increasing transforming growth factor-beta 1 (TGF-β1) expression and inhibitory activities on collagenase and hyaluronidase. The aqueous extract from maceration in gentle heat had the highest total protein content (63 ± 1% w/w), total phenolic content (0.48 ± 0.03 mg GAE/g extract), TGF-β1 stimulating activities (33 ± 2 pg/mL), and collagenase inhibition (with a half maximal inhibitory concentration of 26 ± 1 µg/mL) among various extracts investigated. It caused no irritation to the hen’s egg chorioallantoic membrane and showed no cytotoxicity to human dermal fibroblasts and peripheral blood mononuclear cells. Therefore, aqueous A. domesticus extract is proposed as an innovative natural anti-skin-aging ingredient.
AB - Acheta domesticus is an edible insect, rich in nutritional value and considered a sustainable protein source. This study aimed to investigate the potential application of A. domesticus extracts for anti-skin-aging purposes. The extracts were prepared by maceration at ambient temperature with 95% ethanol or hexane and maceration in gentle heat (45 °C) with 95% v/v ethanol or DI water. The extracts were examined for total protein, phenolic, and flavonoid contents. Protein molecular weight distribution was analyzed. The safety of the extracts was investigated in terms of irritation and cytotoxicity. Biological activities relevant to the inhibition of skin aging were evaluated, including increasing transforming growth factor-beta 1 (TGF-β1) expression and inhibitory activities on collagenase and hyaluronidase. The aqueous extract from maceration in gentle heat had the highest total protein content (63 ± 1% w/w), total phenolic content (0.48 ± 0.03 mg GAE/g extract), TGF-β1 stimulating activities (33 ± 2 pg/mL), and collagenase inhibition (with a half maximal inhibitory concentration of 26 ± 1 µg/mL) among various extracts investigated. It caused no irritation to the hen’s egg chorioallantoic membrane and showed no cytotoxicity to human dermal fibroblasts and peripheral blood mononuclear cells. Therefore, aqueous A. domesticus extract is proposed as an innovative natural anti-skin-aging ingredient.
KW - Acheta domesticus
KW - anti-aging skincare
KW - cosmetic
KW - human dermal fibroblast
KW - safety
U2 - 10.3390/ph17030346
DO - 10.3390/ph17030346
M3 - Journal article
C2 - 38543133
AN - SCOPUS:85189012983
VL - 17
JO - Pharmaceuticals
JF - Pharmaceuticals
SN - 1424-8247
IS - 3
M1 - 346
ER -
ID: 387935182