Unleashing the healing potential: Exploring next-generation regenerative protein nanoscaffolds for burn wound recovery
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Burn injury is a serious public health problem and scientists are continuously aiming to develop promising biomimetic dressings for effective burn wound management. In this study, a greater efficacy in burn wound healing and the associated mechanisms of α-lactalbumin (ALA) based electrospun nanofibrous scaffolds (ENs) as compared to other regenerative protein scaffolds were established. Bovine serum albumin (BSA), collagen type I (COL), lysozyme (LZM) and ALA were separately blended with poly(ε-caprolactone) (PCL) to fabricate four different composite ENs (LZM/PCL, BSA/PCL, COL/PCL and ALA/PCL ENs). The hydrophilic composite scaffolds exhibited an enhanced wettability and variable mechanical properties. The ALA/PCL ENs demonstrated higher levels of fibroblast proliferation and adhesion than the other composite ENs. As compared to PCL ENs and other composite scaffolds, the ALA/PCL ENs also promoted a better maturity of the regenerative skin tissues and showed a comparable wound healing effect to Collagen spongeⓇ on third-degree burn model. The enhanced wound healing activity of ALA/PCL ENs compared to other ENs could be attributed to their ability to promote serotonin production at wound sites. Collectively, this investigation demonstrated that ALA is a unique protein with a greater potential for burn wound healing as compared to other regenerative proteins when loaded in the nanofibrous scaffolds.
Originalsprog | Engelsk |
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Artikelnummer | 100856 |
Tidsskrift | Asian Journal of Pharmaceutical Sciences |
Vol/bind | 18 |
Udgave nummer | 6 |
Antal sider | 13 |
ISSN | 1818-0876 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
This work was financially supported by the Liaoning Pan Deng Xue Zhe Scholar (No. XLYC2002061 ) and the Overseas Expertise Introduction Project for Discipline Innovation (“111 Project”) (No. D20029 ). X. G. acknowledges the Educational Department of Liaoning Province (grant No. LJKZ0925 ), (Youth Project, grant No. LJKQZ2021035), and the international postdoctoral exchange fellowship program (grant No. PC2021047). H. B. thanks the financial support from National Natural Science Foundation of China (grant No. 82050410448 ) and Fellowship of China Postdoctoral Science Foundation (grant No. 2021MD703857 ). D.Cun acknowledges financial support from Ministry of Education Chunhui Program ( 2020 ). VF acknowledges VILLUM FONDEN for supporting the project via the Villum Young Investigator Grant (grant No. 19175 ).
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© 2023
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